Guide to Unlock Marbles Step 1: Unlock Tainted Cain (Spoilers) If you haven't yet, you'll need to unlock Tainted Cain. 9 Prayer Card. Using active items gives a damage up that scales with the charge time, ??? If it touches an enemy it breaks and leave a pool on the floor which freezes enemies and deals 8 damage per tick, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Enemies include Candler, Lil' Haunt, Polty, Red Ghost, Wizoob and The Forsaken, The Haunt, The Heretic and The Rainmaker bosses. poison effect for Pestilence, Added as part of the Afterbirth+ Booster Pack #3. Deals 200 damage to nearby enemies when reviving, Tainted Lilith - All familiars now attach to her Umbilical cord like the Gello item, Tainted Keeper - Nearby coins dropped by enemies move towards you quickly, Tainted Apollyon - Holding the fire button causes locusts to stay near enemies and damage them instead of returning, Tainted Forgotten - Grants the Recall ability. The poison deals your tear damage per tick, for 2 ticks, Has no effect on Lilith, as she cannot fire tears, While firing tears constantly for 7.5 seconds, you spawn a poop cloud, which deals periodic damage to any enemies which come near it, The cloud deals damage equal to your base tear damage per tick, roughly 5 times per second, Clouds last 15 seconds before disappearing, The cloud can be pushed slightly by firing tears at it, Upon taking damage, Isaac starts to bleed, leaving a trail of blood and spraying blood tears everywhere which deal damage to nearby enemies, While bleeding, Isaac takes damage every 30 seconds, The blood sprays in the direction you are current firing, or just randomly near Isaac if not shooting your tears, The blood spray scales with your current tear damage and any future damage increases, This effect lasts until you pick up a red heart, Upon taking damage, this item gives a 25% chance to drop a full red heart, REPENTANCE - This entire item has been reworked, Enemy bullets have a 25% chance to be deflected back at the enemy, which will hurt them and apply the concussive status effect, causing it to be stunned for a few seconds, Every 20th tear fired will also fire a golden coin tear at the same time. UNLOCK: Unlock this trinket by defeating Greedier Mode with ??? When used, turns every normal enemy in the room into poop! I agree with you on Spirit Sword, but I put it in the list because the difficulty to unlock it isn't that high for a tear replacer item that probably impacts your run positively in a major way. This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Having a higher movement speed allows you to kick it harder, Enemies hit by the cube while moving have a high chance to become frozen. HARDHARD. Reveals the location of one secret room on the minimap. Press question mark to learn the rest of the keyboard shortcuts. The new rooms contain 0-3 Devil Deal Items, 1-3 Black Hearts and random enemies from the Sheol floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Judas, Opens the door to the Blue Womb, regardless of whether you meet the 30 minute speed timer, Opening Pandora's Box while holding this item will ignore the normal effect and instead spawn 6 item pedestals from random item pools. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. This effect stacks with multiple shades, scaling the contact damage each time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Judas, Isaac gains a cloud familiar that follows him and leaves a trail of tears on the floor which damages enemies for 2 damage per tick, Enemies touching the cloud have a chance to activate the Crack the Sky effect, which spawns a light beam that deals damage equal to your tear damage + 20, Gives Isaac a small Hush familiar that bounces diagonally around the room dealing 2 contact damage per tick, While you're firing tears Hushy will stop moving, which allows you to keep it in one place, Hushy will block enemy tears and projectiles, UNLOCK: Unlock this item by beating Hush with Apollyon, Gives Isaac a small Monstro familar, who's tears can be charged and released in a shotgun style effect, much like Monstro's main attack, Lil Monstro's tears each deal base damage (3.5) and don't scale with damage upgrades, *, head, cleft, lip, palate, hairlip, tooth, A baby familiar that follows you and causes other familiars to follow it. Shows you to see the contents of chests, sacks, shopkeepers and items that will drop from fires before you destroy them, Doesn't work on tinted rocks and other obstacles (e.g. Ram damage formula has changed to damage * 4 + 28 (previously dealt a static 40 damage). Maggy - +1 HP up. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. In this guide, we'll tell you how to get the Shotgun in Sons of the Forest. This will heal red hearts and then give soul hearts up to a total of 6. Doesn't include Curse Room doors or spiked rocks, Tears can be controlled mid-flight using the directional keys, In addition to regular tears, Isaac will sometimes fire extra spectral tears that orbit around him, Fully heals all your red heart containers, Isaac now emits a large light aura that damages nearby enemies 5 times per second while touching it, The visual effect is similar to the effect given to tears by the GodHead item, The aura deals more damage towards the center, ranging from 0.75 at max range to 4 damage when touching Isaac, In addition to normal tears, Isaac now also fires a set of 4 quadshot tears with a slowing effect, The quadshot tears deal 1.5 damage each and do not scale with your damage upgrades, Upon taking damage, you have a chance to dislodge the spider from your face. Repentance adds more than 100 new enemies, 5,000 new room layouts, 130 new items and much more. Tap the drop button to cycle between each one, Changes all card and rune drops into pills. Aries, Cancer, Capricorn, Leo etc.). treasure room, item room pool, white, Upon use, consumes a coin and deals damage to everything in the room, Damage dealt is equal to your tear damage * 2 + 10, REPENTANCE - Damage buffed, previously it was damage * 2. Spawns another Vurp! All your items and consumables are temporarily removed while in the abandoned mine, The room to access Knife Piece 2 only appears if you have Knife Piece 1 already, You can skip pressing the 3 yellow buttons if you have the ability to fly and have 2 bombs to force open the door, When combined with Knife Piece 1, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, This is a one time use item that teleports you to an alternate floor, which contains every single item in the game, The items are spread between several different rooms all on pedestals. Each use of this item gives +0.7 Damage Up, -0.18 Speed Down and the ability to destroy most obstacles for the current room. Function: Gives access to the Blue Womb no matter the time elapsed, Special interaction with Pandora's Box (consumes both for 6 random items), Unlock Condition: Defeat Isaac, ?? Azazel: Azazel has lots of good devil deal unlocks tied to his completion marks, like Abaddon, The Nail and Maw of the Void. chalice, indiana jones, * angel room pool, god room pool, angel room item, bird, white, Every time you use this item it deals 40 damage to all enemies in the room and Isaac also takes damage, The first use per room takes 1 full heart, then 0.5 hearts per use after that, Shields and invincibility effects do not prevent damage when using this item, Using with Isaac's Heart previously prevented you from taking damage, however in Repentance this was fixed, Using this item as The Lost will instantly kill him, even if you have Holy Mantle active, UNLOCK: Unlock this item by beating Satan with Samson, * item room, treasure room, item room pool, razor, straight, edge, barber, bloody, brown, silver, Follows behind Isaac and can be swung back and forth, dealing 5 contact damage per tick to anything it hits, Every time the hairball kills an enemy, it grows in size allowing it to deal more damage, This is one of the items which allows you to transform into Guppy, Moving to a new floor decreases the size of the hairball, * devil pool, devil room pool, devil deal, grey, brown, pile, guppys hairball, guppy hairball, A familiar that mirrors the player's movements and shoots tears directly at Isaac, Abel's tears do 3.5 damage, unless playing as Cain in which case they do 5, REPENTANCE - Abel now has an increased rate of fire, and will mirror to the other side of the room, even if it's off screen. effect for 10 seconds. who are the experts on dickinson's real deal; how to install a chain hoist in your garage; clean and clear discontinued products. Beyond the womb floor, replaces all coin and key spawns with a random pickup as follows: Bomb - 26.6% chance. The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). Function: Spending money gives out random stat boosts, Unlock Condition: Defeat Mother as Keeper. REPENTANCE - White Pony's charge time has been reduced to 2 (from 6). Tech.5/Technology Zero/Jacobs Ladder: The extra damage is very helpful. Based on the Steam Workshop mod (originally called Hungry Tears) created by Echo, UNLOCK: Unlock this item by taking 10 Tears Up items or pills in the same run, Isaac's tears are replaced with piercing holy flashes of light, which travel across the room in a similar speed to regular tears, Trisagion tears deal roughly 33% of your usual tear damage, however due to the size of the holy flash it is likely to hit enemies multiple times, Trisagion tears cause no knockback on enemies and simply travel through them (piercing tears), Added as part of the Afterbirth+ Booster Pack #4. Void tears that touch enemies will spawn Big Horn, who appears and grabs them, instantly killing that enemy, The chance to for each tear to become a void tear is affected by your luck stat and at +15 Luck it will activate 20% of the time, Isaac also grows a horn on his head, which causes you to deal contact damage to enemies by running into them (this effect deals base damage of 3.5 per tick), Void tears from this item can also destroy blue/purple fires, spiked blocks and stone grimaces, When used, will spawn a fly turret that doesn't move and fires tears at nearby enemies, The fly's bullets deal 3.5 damage each and do not scale with your own damage stat. - Every HP upgrade is now worth 2 soul hearts. Doing so will cause it to increase in size, and also increase their damage and the damage of the burst tears, Once a tear is fed 5 times, it will immediately burst, Tears in the burst will deal half the damage the main tear would have, Added as part of the Afterbirth+ Booster Pack #4. After which, the only way to access an Angel Room is via the Sacrifice Room, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, brown, horns, When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, Based on the Steam Workshop mod created by Niro, A familiar with a charged attack, that spawns a line of creep on the floor which damages enemies that walk over it, The familiar and its creep will change randomly when Isaac uses a pill, Possible creep types include green (deals damage), black (slows enemies), red (deals damage, forms a line with a larger puddle), yellow (deals damage, forms a short-range cone) and white (slows enemies, forms a ring), Added as part of the Afterbirth+ Booster Pack #5. Be warned though, Mom's leg can also stomp and hurt Isaac too! Great list! you could find a caves boss in the basement. The locust fly will do different things for each harbinger - e.g. This is an S tier Angel Room run winner that goes alongside Sacred Heart and Godhead. Spoon Bender will give them a homing effect, and status effects like fear/poison will spread onto all enemies the electricity chains to, Tears which fall naturally to the floor at max range do not generate sparks, It's possible to fire tears at a wall to create electricity that damages enemies on the other side of the wall, *, silver, metal, grey, gray, blue, jacob ladder, jacobs ladder, Each tear now has a small chance to be a spectral blue flame instead, which deals damage to enemies that come in contact with it, The fire will remain in place and shrink in size when deals damage to something. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. Gives Isaac an orbital fly, that will rapidly charge around and deflect any incoming tears that would hit Isaac. It will attempt to hide behind you when shooting. After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. While standing in the aura, Isaac's damage is now also increased by 25%, and his tears gain a homing effect, UNLOCK: Unlock this item by defeating Hush as The Forgotten, A familiar that can be aimed with the fire buttons similar to the Finger item, dealing contact damage to enemies equal to your tear damage, UNLOCK: Unlock this item by defeating Satan as The Forgotten, When used, this item will spawn a bone orbital or charmed Bony for each enemy killed in the current room, The orbitals and charmed enemies persist when travelling between rooms, Bone orbitals break after dealing enough damage or blocking too many shots, UNLOCK: Unlock this item by defeating Delirium in The Void floor as The Forgotten, A passive item that puts a yellow ring around Isaac. Thanks for this list. How do you unlock Godhead? There are some 300 gameplay changes, according to YouTuber IsaacGuru. UNLOCK: Unlock this item by defeating Delirium in The Void floor with Isaac, A one time use active item that when used, will spawn 2 random item pedestals from the item pool associated with the current room (e.g. Unlocked from the 'Once more with the feeling!' *, mustache, moustache, white, yellow, moms toenail, Increases the chance for Black hearts to spawn, UNLOCK: Unlock this item by beating the Dark Room with Eve, * , the lost item pool, grey, gray, makeup, Gives you a higher chance of eternal hearts, Contrary to popular belief, the Bible Tract doesn't allow Angel Rooms to appear after paying for a Devil Deal, * , the lost item pool, grey, gray, black, book, Allows you to unlock golden chests without needing a key, Cain starts with this trinket after donating 68 coins to the Greed Donation Machine, When you reach half a heart of life remaining, a black heart will spawn, After three black hearts have spawned, the trinket dissapears, * , the lost item pool, hand, brown, monkeys paw, monkey's paw, Imitates the behaviours of some of the other 'paper' items/trinkets, A Missing Page: When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect, Has a chance to trigger the Polaroid or Negative effect every time you take damage with half a red heart or less, Missing Poster: Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, achievement (complete a victory lap, defeating the lamb boss), Horf! This is the strongest Shop item in the entire game. binding of isaac: repentance unlock guide deadly premonition 2 enemies lewis and clark called it the seal river codycross . Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. The second piece drops after beating the Boss Rush as long as you are holding the first Broken Shovel piece (see previous 2 items for full details), After The Forgotten is unlocked, using it on the mound of dirt again just spawns a random type of chest, Each time you get hit, you drop a coin or two, REPENTANCE - No longer guaranteed to drop coins as The Keeper, UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll), * , the lost item pool, cent, gold, water, wet, blue, While held, Isaac has a significantly higher chance to find drops when breaking poops, Lowers your spacebar item charge rate by 1, Cannot lower the charge of your spacebar item below 1 room, For example, you will now be able to use a 3 room charge item after 2 rooms instead, Does the teleport effect every time you use your current spacebar item, Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms), Higher chance for champion enemies while held, Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance, Does not attract other pickups like the full Magneto item does, Increases your chances to find an Angel Room instead of a Devil Room, Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. 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