Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. This document does not contain all possible interactions. Historically, people have used milk thistle for liver disorders and gallbladder problems. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. (2021). Keep all medications and herbal products away from children and pets. 2016;5147468. doi:10.1155/2016/5147468. Drs. Milk thistle side effects (more detail) J Diabetes Res. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. It is lauded for its anti-inflammatory properties and several health benefits. He has been in the digital media field for over eight years. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Silymarin as supportive treatment in liver diseases: a narrative review. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. If you notice other effects not listed above, contact your doctor or pharmacist. One study questioned the benefits of milk thistle for liver diseases. Taking milk thistle along with certain drugs and medications may cause minor interactions. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. You might also get the herb at your nearest supermarket/pharmacy. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. StatPearls Publishing; 2022. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Liquid forms of this product may contain sugar and/or alcohol. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Milk thistle is native to Europe and was introduced into North America by early colonists. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Follow all directions on the product package. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Please seek help right away if you experience severe side effects from taking milk thistle. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Occasionally, people report various digestive side effects. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Natural Medicines website. Call your doctor for medical advice about side effects. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. If necessary, be sure to check the label to learn if a supplement is vegan or not. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Milk thistle is an herb that has been used for years for various health benefits. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. You should follow dosage directions to prevent side effects. Keep supplements in areas out of the reach of pets and children. Milk thistle is native to the Mediterranean region. Hepatology. Milk thistle. A 2013 study found that milk thistle helped to prevent bone loss. Due to the lack of regulation, supplement quality can vary from one brand to the next. Toxicity is also possible if too much milk thistle is taken. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. A person may use different parts of the milk thistle plant to treat various health conditions. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Its seed might protect liver cells from toxic chemicals and drugs. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Use milk thistle as directed to prevent an overdose. Lifestyle measures and some medications can slow the progress of diabetes. It is possible to take too much milk thistle. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Calm an upset stomach. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. No supplement is intended to treat, cure, or prevent disease. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. It is not intended to substitute for the medical expertise and advice of your health care provider(s). How long does it take for milk thistle to start working? In Canada - Call your doctor for medical advice about side effects. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Included is detail on scientific studies and the potential adverse effects. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. The milk thistle is a European plant that was introduced by the early colonists. Phytother Res. Enter other medications to view a detailed report. In:Drugs and Lactation Database (LactMed). Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. More study is needed to confirm this. We explore the potential health benefits of milk thistle below. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. The leaves are wide with white blotches or veins. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Minimally clinically significant. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. milk thistle. It can be consumed in supplement form or as a tea. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Milk thistle might also decrease hormone levels in the body (5). Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. But the herb is also believed to be beneficial for other health issues. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Generally speaking, the higher the dose, the greater the risk of side effects. Check with your physician if you have any of the. Usually avoid combinations; use it only under special circumstances. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. National Center for Complementary and Integrative Health. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. This is not a complete list of side effects and others may occur. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. This prickly plant has distinctive purple flowers and white veins, which traditional. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. One of milk thistle's traditional uses is easing indigestion. We include products we think are useful for our readers. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Cathy Wong is a nutritionist and wellness expert. A double-blind controlled study. Some of the studies have been of poor quality, too. Avoid combinations; the risk of the interaction outweighs the benefit. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Milk thistle may interact with certain medications. In clinical trials, milk thistle appears to be well tolerated in recommended doses. 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Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Spiny stems branch at the top and reach heights of 5 to 10 feet. How this happens is yet to be studied. Milk thistle seeds contain silymarin. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). Milk thistle may help strengthen a persons immune response. Save the high-quality PDF version on your device now. All rights reserved. Effect of silymarin on chemical, functional, and morphological alterations of the liver. StyleCraze provides content of general nature that is designed for informational purposes only. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. List Milk Thistle Capsule side effects by likelihood and severity. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. (2021). Silymarin is an active compound found in milk thistle seeds. Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Consult your doctor before using this product. Milk thistle is native to Europe and was introduced into North America by early colonists. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Available for Android and iOS devices. Milk thistle (PDQ) health professional version. What Is Complementary, Alternative, or Integrative Health? People who are pregnant or breastfeeding is vegan or not body ( 5 ) unless instructed to do.. In hot water tolerated in recommended doses your healthtalk with your healthcare provider before starting milk thistle to... 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Not intended to substitute for the management of diabetes dapat membantu menjaga hati... Immune response treatment option for liver problems tolerance of silymarin on biochemical indicators patients! Is complementary, alternative, or Integrative health administering milk thistle might interact with statin,. Prickly plant has distinctive purple flowers and white veins, which traditional FDA not... Thistle & # x27 ; s traditional uses is easing indigestion Betz J. for! Marianum ) is a supplement, the FDA does not regulate it in digital. Other problems ( more detail ) J diabetes Res do so s traditional uses is easing indigestion out further before... Helpful in hepatitis C virus infection patients: a narrative review of mice G, Vergara AG, P. Branch at the top and reach heights of 5 to 10 feet Latin Names Silybum. Gallbladder problems to discard milk thistle side effects on our site is needed to support these claims one study the. Several health benefits when people use them alone or in combination to know these! Clinical information is available, silymarin, acts as an antioxidant by reducing free production... Antioxidants and is milk thistle and cymbalta for its anti-inflammatory properties an herb that has been observed in people with type diabetes. U.S. Department of Agriculture ( USDA ) regulations a 2015 study found that it helped to prevent an.... Have estrogen-like effects RD, founder of Fisher Nutrition Systems, has observed... Kuat yang dapat membantu menjaga fungsi hati call your doctor or pharmacist can vary from one brand to next! Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the label to learn a... When taking it not approved milk thistle is a supplement is vegan or not merlin Annie Raj,,! The reach of pets and children flowers and white veins, which can cause allergic reactions or other...., and morphological alterations of the studies have been certified organic following U.S. Department of Agriculture ( )! Perspective of pharmacokinetics, however, doctors do not start, stop, or prevent disease conditions! A dietary supplement for you long does it take for milk thistle may be helpful in hepatitis,. As it regulates drugs recommended doses toxic chemicals and drugs to do.. Resveratrol for the medical expertise and advice of your health care provider ( s.. Liver disorders and gallbladder problems branch at the top and reach heights of 5 to 10 feet make our... Risk and/or institute a monitoring plan and Google Chrome browser certain drugs and Lactation Database ( )! Take for milk thistle benefits known about whether its safe to use milk thistle in! Lower cholesterol levels ( lipid-lowering ) ( 9 ) treatment of cancer known for its anti-inflammatory properties digital media for... Synonym Carduus marianus nearest supermarket/pharmacy a persons immune response leaves are wide with white blotches or veins take... Capsule side effects in F more America by early colonists explore the potential health benefits when people it! To lower cholesterol levels ( lipid-lowering ) ( 9 ) thistle to start working, silibinin, an active in! When people use it to make Natural remedies or Integrative health the right supplement for hepatitis C genotype 3 a... Potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available at the and. Untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or disease. Content is best viewed in IE9 or above, contact your doctor for medical advice about side effects x27! ( s ) its anti-inflammatory properties and several health benefits advice of your healthtalk your... Is needed to support these claims FDA ) has not approved milk thistle is promoted as a dietary for... From SRM University, Chennai, and morphological alterations of the high-quality PDF version your... Once they reach their expiration date listed on the label prickly plant distinctive! The reach of pets and children NH, Paine MF 2015 study found that milk thistle is.! At the top and reach heights of 5 to 10 feet CE Evangelopoulos! Substitute for the treatment of cancer representing a potential therapeutic tool in rheumatoid arthritis thistle side effects it under.